HIV/AIDS has been at the core of Uganda’s health policy, services and reality for well over two decades. Since the early 1980s, Uganda has been affected by the HIV/AIDS epidemic. To-date, the HIV and AIDS epidemic is generalized in the country with the prevalence in the general population having increased from 6.4% in 2005 to 7.3% in 2011. In light of these worrying and continuous developments, the Young Leaders Think Tank for Policy Alternatives analysed the existing legal and policy framework in Uganda and proposes policy alternatives which could help in the elimination of HIV/AIDS.